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Nifedipine

Structure of Nifedipine

  • Nifedipine is a dihydropyridine derivative featuring a phenyl ring attached to a dihydropyridine core with ethyl and methoxy substituents.

  • Chemical Formula: C₁₅H₁₈N₂O₆

Structure of Nifedipine
Structure of Nifedipine

Mode of Action

  • Calcium Channel Blocking: Selectively inhibits L-type calcium channels in vascular smooth muscle.

  • Vasodilation: Causes significant peripheral vasodilation, lowering blood pressure.

  • Minimal Cardiac Effects: Less impact on myocardial contractility and heart rate compared to non-dihydropyridines.

Uses

  1. Hypertension: Effective in lowering systemic blood pressure.

  2. Angina Pectoris: Reduces chest pain by dilating coronary arteries.

  3. Raynaud’s Phenomenon: Enhances blood flow to extremities.

  4. Preterm Labor: Used off-label to inhibit uterine contractions.


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