Structure of Nifedipine
Nifedipine is a dihydropyridine derivative featuring a phenyl ring attached to a dihydropyridine core with ethyl and methoxy substituents.
Chemical Formula: C₁₅H₁₈N₂O₆
Mode of Action
Calcium Channel Blocking: Selectively inhibits L-type calcium channels in vascular smooth muscle.
Vasodilation: Causes significant peripheral vasodilation, lowering blood pressure.
Minimal Cardiac Effects: Less impact on myocardial contractility and heart rate compared to non-dihydropyridines.
Uses
Hypertension: Effective in lowering systemic blood pressure.
Angina Pectoris: Reduces chest pain by dilating coronary arteries.
Raynaud’s Phenomenon: Enhances blood flow to extremities.
Preterm Labor: Used off-label to inhibit uterine contractions.