Synthesis of Noradrenaline
Conversion from Dopamine
Enzyme: Dopamine β-hydroxylase.
Process: Dopamine is hydroxylated to form noradrenaline (norepinephrine).
Cofactor Required: Ascorbic acid (vitamin C).
Mechanism: The enzyme adds a hydroxyl group to the β-carbon of dopamine, converting it into noradrenaline.
Significance
Attention and Alertness: Noradrenaline enhances focus and response to stimuli.
Fight-or-Flight Response: It activates the sympathetic nervous system, increasing heart rate, blood pressure, and blood glucose levels in response to stress.
Clinical Relevance
Stress Response: Noradrenaline plays a critical role in how the body reacts to stress and emergencies.
