Structure
Norgestrel is a synthetic progestogen with a 19-nor steroid structure, lacking the carbon at position 19 of the progesterone backbone.
Chemical Formula: C₂₀H₂₉NO₂
Mode of Action
Progestogen Activity: Mimics the effects of natural progesterone, regulating the menstrual cycle and preventing ovulation.
Endometrial Stabilization: Thins the endometrial lining, making it unsuitable for implantation.
Cervical Mucus Thickening: Increases viscosity of cervical mucus, impeding sperm penetration.
Uses of Norgestrel
Oral Contraception: Used in combination with estrogens in combined oral contraceptive pills to prevent pregnancy.
Menstrual Disorders: Manages irregular menstrual cycles and reduces menstrual bleeding.
Endometriosis: Helps in reducing the growth of endometrial tissue outside the uterus.