It is a major female sex hormone, and an estrogen steroid hormone.
Structure
Oestradiol Chemical Structure –
Mode of action
Same as oestriol but more potent than oestradiol
A receptor on the target cell is affected by the drug.
Once the oestrogen receptor and its ligand are joined, the oestrogen receptor may enter the nucleus of the target cell and control the transcription of genes, which results in the production of messenger RNA.
To express the effect of estriol on the target cell, certain proteins are produced as a result of an interaction between the mRNA and ribosomes.
Uses
Treatment of advanced androgen-dependent prostate cancer
Hypoestrogenism
Postmenopausal osteoporosis prevention
Vaginal atrophy in menopause.