Oestriol/Estriol

Structure

• Oestriol is one of the three major endogenous estrogens, characterized by a cyclopentanoperhydrophenanthrene structure with three hydroxyl groups.

• Chemical Formula: C₁₈H₂₄O₃

  

Structure of Oestriol

Mode of Action

• Estrogen Receptor Activation: Binds to estrogen receptors, regulating gene transcription involved in reproductive and non-reproductive functions.

• Bone Density Maintenance: Promotes bone formation and inhibits resorption, reducing osteoporosis risk.

• Cardiovascular Health: Enhances lipid profiles and vasodilation, contributing to cardiovascular protection.

• Skin Health: Promotes collagen synthesis and skin elasticity.

Uses

• Hormone Replacement Therapy (HRT): Used in postmenopausal women to alleviate menopausal symptoms.

• Pregnancy Support: Supports the maintenance of pregnancy due to its natural increase during gestation.

• Topical Applications: Employed in creams and ointments for skin conditions and anti-aging effects.

• Cancer Therapy: Investigated for roles in hormone-sensitive cancers, though less commonly used compared to other estrogens.