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Oestriol/Estriol

Structure

  • Oestriol is one of the three major endogenous estrogens, characterized by a cyclopentanoperhydrophenanthrene structure with three hydroxyl groups.

  • Chemical Formula: C₁₈H₂₄O₃

    Chemical formula of Oestriol /Estriol
 Structure of Oestriol
Structure of Oestriol

Mode of Action

  • Estrogen Receptor Activation: Binds to estrogen receptors, regulating gene transcription involved in reproductive and non-reproductive functions.

  • Bone Density Maintenance: Promotes bone formation and inhibits resorption, reducing osteoporosis risk.

  • Cardiovascular Health: Enhances lipid profiles and vasodilation, contributing to cardiovascular protection.

  • Skin Health: Promotes collagen synthesis and skin elasticity.

Uses

  • Hormone Replacement Therapy (HRT): Used in postmenopausal women to alleviate menopausal symptoms.

  • Pregnancy Support: Supports the maintenance of pregnancy due to its natural increase during gestation.

  • Topical Applications: Employed in creams and ointments for skin conditions and anti-aging effects.

  • Cancer Therapy: Investigated for roles in hormone-sensitive cancers, though less commonly used compared to other estrogens.


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