Structure
Oestriol is one of the three major endogenous estrogens, characterized by a cyclopentanoperhydrophenanthrene structure with three hydroxyl groups.
Chemical Formula: C₁₈H₂₄O₃

Mode of Action
Estrogen Receptor Activation: Binds to estrogen receptors, regulating gene transcription involved in reproductive and non-reproductive functions.
Bone Density Maintenance: Promotes bone formation and inhibits resorption, reducing osteoporosis risk.
Cardiovascular Health: Enhances lipid profiles and vasodilation, contributing to cardiovascular protection.
Skin Health: Promotes collagen synthesis and skin elasticity.
Uses
Hormone Replacement Therapy (HRT): Used in postmenopausal women to alleviate menopausal symptoms.
Pregnancy Support: Supports the maintenance of pregnancy due to its natural increase during gestation.
Topical Applications: Employed in creams and ointments for skin conditions and anti-aging effects.
Cancer Therapy: Investigated for roles in hormone-sensitive cancers, though less commonly used compared to other estrogens.