Estrone is a minor female sex hormone, a weak oestrogen, and a steroid.
Structure
Oestrione/Oestrone Chemical Structure –
Mode of action
Same as oestriol but less potent than oestradiol
A receptor on the target cell is affected by the drug.
Once the oestrogen receptor and its ligand are joined, the oestrogen receptor may enter the nucleus of the target cell and control the transcription of genes, which results in the production of messenger RNA.
To express the effect of estriol on the target cell, certain proteins are produced as a result of an interaction between the mRNA and ribosomes.
Uses
To treat perimenopausal sand postmenopausal symptoms.