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Oestrione/Oestrone

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Structure

  • Oestrone is one of the three primary endogenous estrogens, characterized by a cyclopentanoperhydrophenanthrene structure with a ketone group at the 17 position and a hydroxyl group at the 3 positions.

  • Chemical Formula: C₁₈H₂₄O₂

    Chemical formula for Oestrione
Structure of Oestrone
Structure of Oestrone

Mode of Action

  • Estrogen Receptor Activation: Binds to estrogen receptors, regulating gene expression related to reproductive and various systemic functions.

  • Reproductive Functions: Involved in the menstrual cycle, ovulation, and maintenance of the endometrium.

  • Bone Health: Supports bone density by promoting bone formation and inhibiting resorption.

  • Cardiovascular Effects: Enhances lipid profiles and promotes vasodilation, contributing to cardiovascular health.

  • Metabolic Regulation: Influences carbohydrate and lipid metabolism.

Uses of Oestrone

  • Hormone Replacement Therapy (HRT): Sometimes used in HRT regimens to alleviate menopausal symptoms.

  • Contraception: Employed in combination with progestins in certain oral contraceptives.

  • Hormonal Balance: Used in managing hormone-related disorders such as polycystic ovary syndrome (PCOS).

  • Breast Cancer Research: Studied for its role in hormone-sensitive breast cancers.

  • Osteoporosis Prevention: Assists in maintaining bone density in postmenopausal women.


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