Ofloxacin
- BP-S-6-Medicinal Chemistry III
- 3 days ago
- 1 min read
Chemical Structure / Formula of Ofloxacin
Formula: C18H20FN3O4
Structure: A fluorinated quinolone with an oxazine ring (unlike other fluoroquinolones).
Mechanism of Action
Inhibits DNA gyrase (topoisomerase II) and topoisomerase IV, leading to bacterial DNA fragmentation.
Uses
Complicated and uncomplicated UTIs.
Prostatitis, pneumonia, and chlamydial infections.
Alternative for multidrug-resistant TB (MDR-TB).
Side Effects
CNS toxicity (dizziness, headache, confusion).
GI upset (nausea, diarrhea).
Tendon rupture (especially in elderly patients or those on corticosteroids).
QT prolongation, photosensitivity.
