Omeprazole

Structure of Omeprazole

• Omeprazole is a benzimidazole derivative characterized by a pyridine ring fused to a benzimidazole structure with a sulfoxide group and a methoxy group.

• Chemical Formula: C₁₉H₁₉N₃O₃S

Structure of Omeprazole

Mode of Action

• Omeprazole is a proton pump inhibitor (PPI) that irreversibly binds to and inhibits the H⁺/K⁺-ATPase enzyme system (proton pump) in gastric parietal cells.

• This inhibition blocks the final step of gastric acid secretion, leading to a significant and prolonged reduction in stomach acid production.

Uses

1. Peptic Ulcers: Promotes healing by reducing gastric acid secretion.

2. Gastroesophageal Reflux Disease (GERD): Alleviates symptoms by decreasing stomach acidity.

3. Zollinger-Ellison Syndrome: Manages conditions with excessive acid production.

4. Erosive Esophagitis: Heals inflammation and damage to the esophagus.

5. Maintenance Therapy: Prevents recurrence of ulcers and GERD symptoms.