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Organization of skeletal muscle & Muscle Tissue

  • Skeletal muscle is a type of striated muscle tissue responsible for voluntary body movements. It is composed of long, multinucleated cells called muscle fibers.

  • The structure of skeletal muscle can be understood at various levels:

Skeletal muscle fiber

1. Whole muscle:

  • A skeletal muscle is an organ composed of muscle tissue, connective tissue, blood vessels, and nerves.

  • The entire muscle is wrapped in a dense connective tissue called the epimysium.

2. Fascicles:

  • Within the whole muscle, the muscle fibers are organized into bundles called fascicles.

  • Each fascicle is surrounded by a layer of connective tissue called the perimysium.

3. Muscle fibers:

  • Each fascicle contains multiple muscle fibers (muscle cells), which are long, cylindrical, multinucleated cells.

  • Muscle fibers are surrounded by a layer of connective tissue called the endomysium, which contains capillaries and nerves that supply the muscle fibers.

4. Myofibrils:

  • Each muscle fiber contains numerous myofibrils, which are rod-like structures that run parallel to the length of the muscle fiber.

  • Myofibrils are responsible for muscle contraction and are composed of repeating units called sarcomeres.

5. Sarcomeres:

  • The sarcomere is the functional unit of a myofibril and is defined by the area between two Z-lines.

  • It contains thick filaments (myosin) and thin filaments (actin, troponin, tropomyosin), giving skeletal muscle its striated appearance.

6. Sarcoplasmic reticulum (SR) and T-tubules:

  • The sarcoplasmic reticulum (SR) stores and releases calcium ions, which are crucial for muscle contraction.

  • T-tubules are extensions of the muscle cell membrane (sarcolemma) that facilitate the rapid

Muscle Tissue

  • Muscles are soft tissues that can contract to produce movement or maintain posture.

  • There are three main types of muscle tissue:

1. Skeletal Muscle:

  • Location: Attached to bones by tendons.

  • Function: Responsible for voluntary movements.

  • Structure: Long, cylindrical, multinucleated fibers with a striated (banded) appearance.

2. Smooth Muscle:

  • Location: Found in the walls of internal organs and blood vessels.

  • Function: Controls involuntary movements, such as the movement of substances through internal passageways.

  • Structure: Spindle-shaped, single-nucleated fibers without striations.

3. Cardiac Muscle:

  • Location: Found exclusively in the heart.

  • Function: Pumps blood throughout the body.

  • Structure: Branched, cylindrical fibers with one or two centrally located nuclei, striated, and connected by intercalated discs for coordinated contractions.


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