Packaging and storage of suppositories are crucial to maintain their quality, stability, and efficacy throughout their shelf life.
Suppositories are susceptible to changes in temperature, humidity, and light, which can affect their physical and chemical properties.
Proper packaging and storage practices can help protect suppositories from these factors.
Packaging of suppositories:
Suppositories should be individually wrapped in materials that provide an effective barrier against moisture and contaminants. Common packaging materials include aluminium foil, PVC or PVDC films, and laminated materials.
Individually wrapped suppositories can be further packaged in secondary containers, such as boxes or plastic containers, to provide additional protection during transportation and storage.
The packaging materials should be compatible with the suppository base and the active pharmaceutical ingredient (API) to prevent any chemical reactions or changes in the product's properties.
The packaging should include clear and accurate labeling with information such as the product name, dosage strength, usage instructions, storage conditions, expiry date, and any necessary warnings.
Storage:
Suppositories should be stored in a cool, dry place, away from direct sunlight and heat sources. The ideal storage temperature for most suppositories is around 15-25°C (59-77°F), although specific storage conditions may vary depending on the product.
Temperature-sensitive suppositories, such as those containing cocoa butter, may require refrigeration to maintain their stability and prevent melting. In such cases, the suppositories should be allowed to come to room temperature before use to avoid discomfort upon administration.
To maintain their quality and efficacy, suppositories should be stored in their original packaging until they are ready to be used. This helps protect them from environmental factors and potential contamination.