Structure of Pantoprazole
Pantoprazole is a benzimidazole derivative characterized by a pyridine ring fused to a benzimidazole structure, containing a sulfoxide group and a pyridine-containing side chain.
Chemical Formula: C₁₈H₁₉N₃O₄S
Mode of Action
Pantoprazole acts as a proton pump inhibitor by selectively and irreversibly binding to the H⁺/K⁺-ATPase enzyme in gastric parietal cells.
This binding block gastric acid secretion, leading to decreased stomach acidity.
Uses
Peptic Ulcers: Promotes healing by reducing acid secretion.
GERD: Manages symptoms by decreasing gastric acidity.
Zollinger-Ellison Syndrome: Controls excessive production of stomach acid.
Erosive Esophagitis: Facilitates healing of esophageal lesions.
Maintenance Therapy: Prevents recurrence of ulcer and GERD symptoms.