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Pantoprazole

Structure of Pantoprazole

  • Pantoprazole is a benzimidazole derivative characterized by a pyridine ring fused to a benzimidazole structure, containing a sulfoxide group and a pyridine-containing side chain.

  • Chemical Formula: C₁₈H₁₉N₃O₄S

Mode of Action

  • Pantoprazole acts as a proton pump inhibitor by selectively and irreversibly binding to the H⁺/K⁺-ATPase enzyme in gastric parietal cells.

  • This binding blocks gastric acid secretion, leading to decreased stomach acidity.

Uses

  1. Peptic Ulcers: Promotes healing by reducing acid secretion.

  2. GERD: Manages symptoms by decreasing gastric acidity.

  3. Zollinger-Ellison Syndrome: Controls excessive production of stomach acid.

  4. Erosive Esophagitis: Facilitates healing of esophageal lesions.

  5. Maintenance Therapy: Prevents recurrence of ulcer and GERD symptoms.


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