Pantoprazole

Structure of Pantoprazole

• Pantoprazole is a benzimidazole derivative characterized by a pyridine ring fused to a benzimidazole structure, containing a sulfoxide group and a pyridine-containing side chain.

• Chemical Formula: C₁₈H₁₉N₃O₄S

Structure of Pantoprazole

Mode of Action

• Pantoprazole acts as a proton pump inhibitor by selectively and irreversibly binding to the H⁺/K⁺-ATPase enzyme in gastric parietal cells.

• This binding blocks gastric acid secretion, leading to decreased stomach acidity.

Uses

1. Peptic Ulcers: Promotes healing by reducing acid secretion.

2. GERD: Manages symptoms by decreasing gastric acidity.

3. Zollinger-Ellison Syndrome: Controls excessive production of stomach acid.

4. Erosive Esophagitis: Facilitates healing of esophageal lesions.

5. Maintenance Therapy: Prevents recurrence of ulcer and GERD symptoms.