Pentaerythritol tetranitrate

Structure of Pentaerythritol tetranitrate

• Pentaerythritol tetranitrate (PETN) is a nitrate ester of pentaerythritol, featuring four nitrate groups esterified to the hydroxyl groups of pentaerythritol.

• Chemical Formula: C₅H₈N₃O₁₈

Structure of Pentaerythritol tetranitrate

Mode of Action

• Nitric Oxide Release: PETN metabolizes to release NO, causing vasodilation.

• Vasodilation: Similar to other nitrates, it relaxes vascular smooth muscle, reducing preload and afterload.

• Platelet Inhibition: Exhibits antiplatelet effects, reducing the risk of thrombosis.

Uses

1. Angina Pectoris: Prevents anginal attacks by improving myocardial oxygen supply.

2. Heart Failure: Used as part of multi-drug regimens to manage symptoms.

3. Hypertension: Adjunctive treatment in hypertensive emergencies.

4. Explosives: Although primarily a vasodilator, PETN is also used as an explosive due to its nitrate ester structure.t issues.