Structure of Pentaerythritol tetranitrate
Pentaerythritol tetranitrate (PETN) is a nitrate ester of pentaerythritol, featuring four nitrate groups esterified to the hydroxyl groups of pentaerythritol.
Chemical Formula: C₅H₈N₃O₁₈
Mode of Action
Nitric Oxide Release: PETN metabolizes to release NO, causing vasodilation.
Vasodilation: Similar to other nitrates, it relaxes vascular smooth muscle, reducing preload and afterload.
Platelet Inhibition: Exhibits antiplatelet effects, reducing the risk of thrombosis.
Uses
Angina Pectoris: Prevents anginal attacks by improving myocardial oxygen supply.
Heart Failure: Used as part of multi-drug regimens to manage symptoms.
Hypertension: Adjunctive treatment in hypertensive emergencies.
Explosives: Although primarily a vasodilator, PETN is also used as an explosive due to its nitrate ester structure.t issues.