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Pentamidine Isethionate: Chemical Structure, Mechanism of Action, Uses & Side effects

sachinkumar244
1 min read

Chemical formula:

  • C19H24N4O2·2C6H8O7

Structure of Pentamidine Isethionate
Structure of Pentamidine Isethionate

Mechanism of action:

  • Pentamidine is an aromatic diamidine that likely interferes with the DNA and RNA synthesis in the protozoan parasite Trypanosoma species, resulting in cell death.

Uses:

  • Pentamidine isethionate is primarily used to treat African trypanosomiasis (sleeping sickness) and Pneumocystis jirovecii pneumonia (PCP) in HIV-infected patients. It is also used to treat and prevent leishmaniasis and trypanosomiasis in certain cases.

Side effects:

  • Common side effects include gastrointestinal disturbances (nausea, vomiting, diarrhea), hypotension, dizziness, and renal toxicity. Other side effects may include anemia, leukopenia, hypoglycemia, or pancreatitis.

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