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Phenacaine

BP-S-5-MEDICINAL CHEMISTRY
1 min read

Structure

  • Phenacaine is an amino benzoic acid derivative with a propyl ester group, providing effective local anesthetic properties.

  • Chemical Formula: C₁₀H₂₀N₂O₂

    formula of Phenacaine
Structure of Phenacaine
Structure of Phenacaine

Mode of Action

  • Sodium Channel Blockade: Inhibits voltage-gated sodium channels, preventing nerve impulse conduction.

  • Membrane Stabilization: Enhances nerve membrane stability, reducing excitability.

Uses

  • Local Anesthesia: Applied in dental procedures, minor surgeries, and ophthalmic preparations.

  • Topical Preparations: Used in creams, gels, and sprays for localized pain relief.

  • Ophthalmic Anesthesia: Employed in eye surgeries for corneal numbing.

Side Effects

  • Local Irritation: Redness, swelling, or discomfort at the application site.

  • Systemic Toxicity: Rare but possible with excessive use, leading to CNS and cardiovascular effects.


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