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Phentolamine: Chemical Structure, Mechanism of Action, Uses & Side Effects

Chemical Structure/Formula:

  • C17H19N3O

Structure of Phentolamine
Structure of Phentolamine

Mechanism of Action:

  • Phentolamine is a non-selective alpha-adrenergic antagonist. It blocks alpha-1 and alpha-2 receptors, which leads to vasodilation and a decrease in blood pressure.

Uses:

  • It is used to treat high blood pressure caused by pheochromocytoma (a type of adrenal gland tumor). It is also used to prevent tissue necrosis following the extravasation of noradrenaline.

Side Effects:

  • Common side effects include hypotension, tachycardia, flushing, and headache. It may also cause gastrointestinal upset and nasal congestion.

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