Definition
Phytosomes are advanced herbal drug delivery systems designed to improve the absorption and bioavailability of plant-based compounds.
They form a complex between phytoconstituents (active herbal molecules) and phospholipids, enhancing the effectiveness of herbal medicines.
Why Phytosomes?
Many herbal compounds, such as flavonoids and polyphenols, have poor solubility and low absorption in the body.
Phytosomes help overcome these limitations by increasing solubility, stability, and permeability, leading to better therapeutic effects.
How Phytosomes Work
In a phytosome, the herbal active ingredient (e.g., curcumin from turmeric) is bound to phospholipids (e.g., phosphatidylcholine).
The phospholipid coating makes the herbal compound more fat-soluble, facilitating easier passage through cell membranes.
This significantly improves bioavailability, ensuring better absorption and utilization by the body.
Phytosome Formulation Process
Selection of Active Ingredient: Chosen based on therapeutic properties.
Selection of Phospholipids: Must form a stable complex with the herb.
Preparation of Phospholipid Dispersion: Phospholipid is dissolved in a suitable solvent.
Mixing with Active Ingredient: Combined under controlled conditions to form phytosomes.
Purification: Removes impurities to ensure stability.
