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Pioglitazone

Structure

  • Pioglitazone is a TZD with a thiazolidinedione ring substituted with a pyridine moiety, enhancing its binding affinity to PPAR-γ.

  • Chemical Formula: C₁₄H₁₈N₂O₂S

    Pioglitazone
Structure of Pioglitazone
Structure of Pioglitazone

Mode of Action

  • PPAR-γ Agonism: Enhances insulin sensitivity by modulating gene expression related to glucose and lipid metabolism.

  • Adipocyte Differentiation: Promotes the formation of insulin-sensitive adipocytes.

Uses

  • Type 2 Diabetes Mellitus: Improves glycemic control by increasing insulin sensitivity.

  • Dyslipidemia: Reduces triglycerides and increases HDL cholesterol levels.

  • Non-Alcoholic Steatohepatitis (NASH): Investigated for its role in reducing liver fat and inflammation.


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