Chemical Structure:
C7H9ClN2O
Mechanism of Action:
Pralidoxime chloride is a cholinesterase reactivator. It works by binding to the organophosphate-inhibited acetylcholinesterase enzyme and breaks the phosphorus-enzyme bond.
This reactivates the enzyme and allows it to resume its role in breaking down acetylcholine in the synaptic cleft.
Uses:
It is used as an antidote for organophosphate poisoning (such as from certain pesticides and nerve gases), which can cause severe muscle weakness and potentially fatal respiratory failure.
Side Effects:
Side effects may include blurred vision, double vision, difficulty swallowing, dizziness, headache, drowsiness, nausea, stomach pain, nervousness, restlessness, rapid heartbeat, and hives or rash.
In rare cases, it can cause high blood pressure and pulmonary edema.