Structure
Prednisolone is a synthetic glucocorticoid with a modified steroid structure, enhancing its anti-inflammatory potency.
Chemical Formula: C₂₀H₂₈O₅
Mode of Action
Glucocorticoid Activity: Binds to glucocorticoid receptors, regulating gene transcription involved in inflammatory and immune responses.
Anti-Inflammatory Effects: Suppresses the production of pro-inflammatory cytokines and mediators.
Immunosuppression: Inhibits immune cell proliferation and function, reducing autoimmune and hypersensitivity reactions.
Metabolic Effects: Alters carbohydrate, protein, and lipid metabolism, influencing glucose levels and fat distribution.
Uses of Prednisolone
Inflammatory Conditions: Treats arthritis, asthma, and allergic reactions by mitigating inflammation.
Autoimmune Diseases: Manages lupus, multiple sclerosis, and inflammatory bowel disease through immunosuppression.
Endocrine Disorders: Used in adrenal insufficiency to replace deficient cortisol.
Skin Disorders: Applied topically to reduce inflammation and treat dermatitis, eczema, and psoriasis.
Cancer Therapy: Adjunct in chemotherapy regimens to reduce inflammation and manage side effects.