Chemical Structure / Formula
Formula: C15H21N3O · H3PO4
Structure: 8-Aminoquinoline derivative.
Mechanism of Action
Disrupts mitochondrial electron transport and generates reactive oxygen species (ROS), killing liver-stage (hypnozoites) and gametocytes of Plasmodium.
Uses
Radical cure of P. vivax and P. ovale malaria (eradicates hypnozoites).
Prevents transmission (gametocidal effect).
Side Effects
Hemolysis in G6PD deficiency.
Methemoglobinemia, GI distress.
