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Progesterones

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Structure

  • Progesterones are a group of steroid hormones with a cyclopentanoperhydrophenanthrene structure, featuring ketone and hydroxyl functional groups at specific positions.

  • Chemical Formula: C₂₀H₃₀O₂

    Progesterones
Structure of Progesterones
Structure of Progesterones

Mode of Action

  • Progesterone Receptor Activation: Binds to progesterone receptors in target tissues, regulating gene expression.

  • Reproductive Role: Prepares the endometrium for implantation, maintains pregnancy, and regulates the menstrual cycle.

  • Neuroprotective Effects: Exhibits protective roles in the central nervous system.

  • Anti-inflammatory Actions: Modulates immune responses and reduces inflammation.

Uses of Progesterones

  • Contraception: Combined with estrogens in oral contraceptives to prevent ovulation and implantation.

  • Menstrual Disorders: Manages irregular menstrual cycles, premenstrual syndrome (PMS), and endometriosis.

  • Hormone Replacement Therapy (HRT): Used in postmenopausal women to prevent endometrial hyperplasia when combined with estrogens.

  • Assisted Reproductive Technology (ART): Supports implantation and maintenance of early pregnancy.


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