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Pyrazinamide

Chemical Structure / Formula of Pyrazinamide

  • Formula: C5H5N3O

  • Structure: A nicotinamide analog.

Chemical Structure of Pyrazinamide

Mechanism of Action

  • Prodrug converted into pyrazinoic acid (POA) by pyrazinamidase (pncA enzyme).

  • POA disrupts membrane potential and fatty acid synthesis, leading to bacterial death.

Uses

  • First-line TB treatment, especially in short-course regimens.

Side Effects

  • Hepatotoxicity, hyperuricemia (gout), GI upset.


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