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Quercetin: Occurrence, Chemical Nature and Medicinal Benefits

  • This is a widely distributed flavonoid in onions, apples, berries, and tea.

  • Quercetin's benefits include reducing inflammation, acting as an antihistamine to alleviate allergy symptoms, and potentially protecting against heart disease and certain cancers.

Occurrence:

  • Quercetin is widely distributed in the plant kingdom.

  • It is found in many fruits, vegetables, leaves, and grains. Key dietary sources include onions, apples, grapes (and wine), berries, broccoli, citrus fruits, and tea.

Chemical Nature:

  • Quercetin is a flavonol, a subclass of flavonoids, known for its yellow crystalline pigment.

  • Its chemical structure consists of a benzo-γ-pyrone ring system, which is responsible for its antioxidant properties.

  • As a polyphenolic compound, quercetin possesses several hydroxyl groups attached to its rings, making it highly effective at scavenging free radicals.

Medicinal Benefits:

1. Antioxidant Activity:

  • Quercetin is a powerful antioxidant that helps in protecting the body from free radicals, reducing the risk of oxidative stress and related chronic diseases.

2. Anti-inflammatory Effects:

  • It has been shown to reduce inflammation by inhibiting the production of inflammatory cytokines and enzymes.

3. Heart Health:

  • Quercetin may contribute to heart health by improving endothelial function, reducing blood pressure, and preventing the oxidation of low-density lipoprotein (LDL) cholesterol.

4. Antihistamine and Anti-allergic Properties:

  • It can help in managing allergy symptoms by inhibiting histamine release from mast cells.

5. Potential Anti-cancer Effects:

  • Research suggests that quercetin may inhibit cancer cell growth and induce apoptosis in various types of cancer cells.


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