Structure of Quinapril hydrochloride
Quinapril hydrochloride is a prodrug ACE inhibitor with a quinoline ring fused to a pyrrolidine moiety.
Chemical Formula: C₂₈H₃₈N₃O₆S·HCl
Mode of Action
Prodrug Activation: Converted to quinaprilat, the active metabolite.
ACE Inhibition: Blocks the formation of angiotensin II, promoting vasodilation.
Vasodilation: Reduces systemic vascular resistance and arterial pressure.
Renal Effects: Decreases glomerular pressure, offering renal protection.
Uses
Hypertension: Lowers blood pressure by inhibiting ACE activity.
Heart Failure: Enhances cardiac performance by reducing afterload and preload.
Post-Myocardial Infarction: Prevents adverse cardiac remodeling and improves survival.
Diabetic Nephropathy: Slows the progression of kidney damage in diabetic patients..