top of page
Search

Quinapril hydrochloride

BP-S-5-MEDICINAL CHEMISTRY
1 min read

Structure of Quinapril hydrochloride

  • Quinapril hydrochloride is a prodrug ACE inhibitor with a quinoline ring fused to a pyrrolidine moiety.

  • Chemical Formula: C₂₈H₃₈N₃O₆S·HCl

Structure of Quinapril hydrochloride
Structure of Quinapril hydrochloride

Mode of Action

  • Prodrug Activation: Converted to quinaprilat, the active metabolite.

  • ACE Inhibition: Blocks the formation of angiotensin II, promoting vasodilation.

  • Vasodilation: Reduces systemic vascular resistance and arterial pressure.

  • Renal Effects: Decreases glomerular pressure, offering renal protection.

Uses

  1. Hypertension: Lowers blood pressure by inhibiting ACE activity.

  2. Heart Failure: Enhances cardiac performance by reducing afterload and preload.

  3. Post-Myocardial Infarction: Prevents adverse cardiac remodeling and improves survival.

  4. Diabetic Nephropathy: Slows the progression of kidney damage in diabetic patients.


bottom of page