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Quinidine Sulphate

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Structure

  • Quinidine sulphate is a stereoisomer of quinine, belonging to the class IA antiarrhythmic agents.

  • It features a quinoline structure with a stereocenter that distinguishes it from quinine.

  • Chemical Formula: C₂₄H₂₉NO₄S (C24H29NO4S)

Structure of Quinidine Sulphate
Structure of Quinidine Sulphate

Mode of Action

  • Class IA Antiarrhythmic: Prolongs the action potential and refractory period by blocking fast sodium channels.

  • Ventricular and Atrial Myocytes: Slows phase 0 of the cardiac action potential, reducing excitability.

  • Potassium Channel Blockade: Extends repolarization by inhibiting potassium efflux.

  • Effect on Heart Rate: Can convert atrial fibrillation to sinus rhythm and prevent reentrant arrhythmias.

Uses of Quinidine Sulphate

  • Atrial Fibrillation and Flutter: Restores and maintains sinus rhythm.

  • Ventricular Tachycardia: Treats and prevents ventricular arrhythmias.

  • Prevention of Reentrant Arrhythmias: Effective in various supraventricular and ventricular arrhythmias.

  • Antiarrhythmic Prophylaxis: Prevents recurrence of arrhythmias post-cardiac surgery or myocardial infarction.


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