Rabeprazole

Structure of Rabeprazole

• Rabeprazole is a benzimidazole derivative with a pyridine ring fused to a benzimidazole core, containing a sulfone group and an ethoxy methyl group.

• Chemical Formula: C₁₈H₂₀N₄O₅S

Structure of Rabeprazole

Mode of Action

• Rabeprazole functions as a proton pump inhibitor by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme in gastric parietal cells.

• It blocks the final step of acid production, resulting in prolonged acid suppression.

Uses

1. Peptic Ulcers: Aids in ulcer healing by reducing gastric acid.

2. GERD: Alleviates acid reflux symptoms.

3. Zollinger-Ellison Syndrome: Manages excessive gastric acid secretion.

4. Erosive Esophagitis: Heals damage and inflammation in the esophagus.

5. Helicobacter pylori Eradication: Part of combination therapy to eliminate H. pylori infection.