Structure of Ranitidine
Ranitidine is a second-generation H₂-receptor antagonist featuring a furan ring connected to a dimethylamine side chain and a nitro group.
Chemical Formula: C₁₉H₂₈N₄O₃S
Mode of Action
Ranitidine selectively blocks H₂ receptors on gastric parietal cells, thereby inhibiting gastric acid secretion.
It has a longer duration of action and greater receptor selectivity compared to first-generation H₂ antagonists.
Uses
Peptic Ulcers: Promotes ulcer healing by reducing acid levels.
GERD: Alleviates heartburn and acid reflux symptoms.
Zollinger-Ellison Syndrome: Manages conditions with excessive acid secretion.
Prevention of Stress Ulcers: Used in hospitalized patients to prevent ulcer development.