Reactions of Cyclopropane
- S-3-PHARMACEUTICAL-ORGANIC-CHEMISTRY
- Feb 28
- 1 min read
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Cyclopropane is a three-membered ring with significant angle strain due to its 60° bond angles (compared to the ideal 109.5° for sp³ hybridized carbons).
This strain makes cyclopropane relatively reactive, particularly in reactions that relieve this strain.
Hydrogenation
Cyclopropane can be hydrogenated in the presence of a metal catalyst (like Pd/C) to form propane. The reaction breaks the strained C–C bonds and saturates the molecule.
Cyclopropane + H2 → Pd/C (reagents)→ Propane
Halogenation
Cyclopropane reacts with halogens (like chlorine or bromine) under light (hv) or heat to form 1,3-dihalopropane, breaking the ring and relieving strain.
Cyclopropane + X2 → hv (reagents)→ 1,3-Dihalopropane (X=Cl,Br)
Reaction with HX (Hydrohalogenation)
Cyclopropane reacts with hydrogen halides (e.g., HCl, HBr) to form 1-haloalkanes (e.g., propyl halides), breaking the ring structure.
Cyclopropane + HX → 1-Halopropane
Addition of Carbenes
Cyclopropane can undergo ring expansion when reacted with carbenes, leading to cyclobutanes or other cyclic compounds, depending on the nature of the carbene.
Cyclopropane + Carbene → Cyclobutane (or other derivatives)
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