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Repaglinide

BP-S-5-MEDICINAL CHEMISTRY
1 min read

Structure

  • Repaglinide is a meglitinide derivative with a pyridine ring, enhancing its binding affinity to pancreatic K⁺ channels.

  • Chemical Formula: C₁₀H₁₂N₂O

    Formula of Repaglinide
Structure of Repaglinide
Structure of Repaglinide

Mode of Action

  • K⁺ Channel Blockade: Stimulates insulin release by blocking ATP-sensitive K⁺ channels in pancreatic beta cells.

  • Rapid Onset and Short Duration: Targets postprandial hyperglycemia without causing prolonged hypoglycemia.

Uses

  • Type 2 Diabetes Mellitus: Controls postprandial blood glucose levels.

  • Combination Therapy: Often used with metformin or other antidiabetic agents for comprehensive glycemic control.


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