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Rifampicin: Chemical structure, Mechanism of Action, Uses & Side effects

Chemical formula:

  • C43H58N4O12

Structure of Rifampicin
Structure of Rifampicin

Mechanism of action:

  • Rifampicin binds to the beta subunit of bacterial DNA-dependent RNA polymerase, inhibiting RNA synthesis and thereby preventing bacterial replication.

Uses:

  • Rifampicin is used in combination with other antitubercular drugs for the treatment of tuberculosis (TB).

  • It is also used for the treatment of other bacterial infections, such as leprosy and certain staphylococcal and meningococcal infections.

Side effects:

  • Side effects can include hepatotoxicity, gastrointestinal disturbances, hypersensitivity reactions, flu-like syndrome, and red-orange discoloration of body fluids.



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