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Rosiglitazone

BP-S-5-MEDICINAL CHEMISTRY
1 min read

Structure

  • Rosiglitazone is a TZD with a similar core structure to pioglitazone but contains a different aromatic substituent, enhancing its potency.

  • Chemical Formula: C₁₉H₂₅N₃O₃S

Formula of Rosiglitazone

Structure of Rosiglitazone
Structure of Rosiglitazone

Mode of Action

  • PPAR-γ Agonism: Increases insulin sensitivity in peripheral tissues.

  • Anti-Inflammatory Effects: Reduces inflammatory markers associated with insulin resistance.

Uses

  • Type 2 Diabetes Mellitus: Enhances insulin sensitivity to improve glycemic control.

  • Metabolic Syndrome: Assists in managing insulin resistance and dyslipidemia.

Note

  • Cardiovascular Risks: Associated with increased risk of myocardial infarction; usage restricted or monitored closely in many regions.


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