Solubility Expressions

• Solubility Expressions is a fundamental concept in physical pharmaceutics that influences the formulation, efficacy, and bioavailability of drugs.
• Understanding the solubility of drugs is crucial for developing effective pharmaceutical products.
• Solubility can be expressed in various ways, depending on the context and the required precision:

1. Qualitative Solubility Expressions:

   • Very Soluble: Less than 1 part solvent needed to dissolve 1 part solute.
   • Freely Soluble: From 1 to 10 parts solvent.
   • Soluble: From 10 to 30 parts solvent.
   • Sparingly Soluble: From 30 to 100 parts solvent.
   • Slightly Soluble: From 100 to 1,000 parts solvent.
   • Very Slightly Soluble: From 1,000 to 10,000 parts solvent.
   • Practically Insoluble (or Insoluble): More than 10,000 parts solvent.

2. Quantitative Expressions:

   • Molar Solubility: The number of moles of solute that can dissolve in a liter of solution (mol/L).
   • Mass/Volume Solubility: The mass of solute that can dissolve in a given volume of solvent (mg/mL).
   • Percentage: The amount of solute per 100 parts of solution, expressed as a percentage (w/v, w/w, v/v).

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