Spironolactone

Structure of Spironolactone

• Spironolactone is a steroidal potassium-sparing diuretic with a fused cyclohexene and lactone ring structure, containing a sulfonamide group.

• Chemical Formula: C₂₈H₃₉ClN₂O₄S

Structure of Spironolactone

Mode of Action

• Aldosterone Antagonism: Blocks aldosterone receptors in the distal nephron, inhibiting sodium reabsorption and potassium excretion.

• Sodium Excretion: Promotes excretion of sodium and water without significant loss of potassium.

• Anti-androgen Effects: Exhibits anti-androgenic properties, useful in treating hormonal disorders.

Uses

1. Heart Failure: Reduces fluid retention and prevents potassium loss.

2. Hypertension: Lowers blood pressure by promoting sodium excretion.

3. Edema: Manages edema associated with liver cirrhosis and renal disease.

4. Primary Hyperaldosteronism: Treats conditions with excess aldosterone production.

5. Acne and Hirsutism: Utilized for its anti-androgenic effects in dermatological conditions.