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Storage Conditions, Precautions, and Pharmaceutical Applications of Radioactive Substances

Storage Conditions:

1.Shielding:

  • Use appropriate shielding materials to reduce radiation exposure.

  • Lead containers or bricks are suitable for gamma emitters, while plexiglass or acrylic is effective for beta emitters.

  • Alpha emitters can be stored in sealed containers as they can be blocked by container walls or even paper.

2.Ventilation:

  • Store radioactive materials in well-ventilated areas to prevent the buildup of radioactive gases like radon.

3.Segregation:

  • Store radioactive substances separately from other chemicals in designated areas.

  • Different types of radioactive materials should be kept separate, clearly labeled, and organized.

4.Restricted Access:

  • Limit access to storage areas to authorized personnel who have received appropriate training in handling and safety procedures.

5.Monitoring:

  • Conduct regular radiation monitoring in storage areas to ensure radiation levels remain within acceptable limits.

Precautions:

1.Training:

  • Ensure personnel handling radioactive materials receive proper training in radiation safety, handling procedures, and emergency response.

2.Personal Protective Equipment (PPE):

  • Wear appropriate PPE, such as lab coats, gloves, and safety glasses. Additional protective clothing, like lead aprons, may be necessary for handling gamma emitters.

3.Dosimetry:

  • Workers should wear dosimeters to monitor radiation exposure levels.

4.Contamination Control:

  • Cover work surfaces with absorbent, disposable materials to contain spills.

  • Regular surveys should detect contamination, and proper decontamination procedures should be followed if needed.

5.Waste Disposal:

  • Segregate, collect, and dispose of radioactive waste according to local regulations and guidelines.

Pharmaceutical Applications:

1.Diagnostic Imaging:

  • Radioisotopes like technetium-99m and fluorine-18 are used as tracers in imaging techniques such as SPECT and PET scans.

2.Radiation Therapy:

  • Radioisotopes like iodine-131 and yttrium-90 are used to treat cancer by delivering targeted radiation to malignant cells.

3.Radiopharmaceuticals:

  • Drugs containing radioactive substances used for diagnostic and therapeutic purposes, requiring strict manufacturing and regulatory control to ensure quality, safety, and efficacy.


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