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Sulphapyridine

Chemical Structure / Formula of Sulphapyridine

  • Formula: C11H11N3O2S

  • Structure: Sulfonamide group attached to a pyridine ring.

Chemical Structure of Sulphapyridine

Mechanism of Action

  • Inhibits dihydropteroate synthase, blocking folic acid synthesis in bacteria.

  • Bacteriostatic effect.

Uses

  • Used in the past for bacterial infections (e.g., pneumonia, UTIs).

  • Largely replaced by newer sulfonamides due to side effects.

  • Component of sulfasalazine (metabolized in the colon to sulfapyridine and 5-ASA).

Side Effects

  • GI upset, rash, fever.

  • Risk of Stevens-Johnson syndrome.

  • Crystalluria, hemolysis in G6PD-deficient patients


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