Structure
Tadalafil is a PDE5 inhibitor with a similar core structure to sildenafil but with distinct substituents enhancing its pharmacokinetic profile.
Chemical Formula: C₂₂H₂₉N₃O₄
Mode of Action
PDE5 Inhibition: Tadalafil selectively inhibits PDE5, preventing the breakdown of cGMP.
cGMP Elevation: Leads to prolonged smooth muscle relaxation and vasodilation in the corpus cavernosum.
Sustained Erection: Facilitates erection by enhancing blood flow in response to sexual stimulation, with a longer duration of action compared to sildenafil.
Uses of Tadalafil
Erectile Dysfunction (ED): Treats erectile dysfunction by enhancing the natural erectile response.
Benign Prostatic Hyperplasia (BPH): Alleviates symptoms of BPH, such as difficulty in urination.
Pulmonary Arterial Hypertension (PAH): Used to lower pulmonary blood pressure, marketed as Adcirca®.