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Tadalafil

Structure

  • Tadalafil is a PDE5 inhibitor with a similar core structure to sildenafil but with distinct substituents enhancing its pharmacokinetic profile.

  • Chemical Formula: C₂₂H₂₉N₃O₄

    formula of Tadalafil
Structure of Tadalafil
Structure of Tadalafil

Mode of Action

  • PDE5 Inhibition: Tadalafil selectively inhibits PDE5, preventing the breakdown of cGMP.

  • cGMP Elevation: Leads to prolonged smooth muscle relaxation and vasodilation in the corpus cavernosum.

  • Sustained Erection: Facilitates erection by enhancing blood flow in response to sexual stimulation, with a longer duration of action compared to sildenafil.

Uses of Tadalafil

  • Erectile Dysfunction (ED): Treats erectile dysfunction by enhancing the natural erectile response.

  • Benign Prostatic Hyperplasia (BPH): Alleviates symptoms of BPH, such as difficulty in urination.

  • Pulmonary Arterial Hypertension (PAH): Used to lower pulmonary blood pressure, marketed as Adcirca®.


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