Structure of Thiotepa
Thiotepa is a trivalent phosphoramide alkylating agent containing three chloroethyl groups attached to a nitrogen atom.
Chemical Formula: C₆H₁₃Cl₃N₄O₂P
Mode of Action
DNA Alkylation: Forms crosslinks within and between DNA strands, inhibiting DNA replication and transcription.
Cell Cycle Arrest: Halts cancer cell division.
Apoptosis Induction: Promotes programmed cell death in malignant cells.
Uses
Breast Cancer: Particularly in metastatic cases.
Ovarian Cancer: As part of combination chemotherapy.
Multiple Myeloma: Treatment in conjunction with other agents.
Central Nervous System (CNS) Cancers: Such as primary brain tumors.
Bone Marrow Transplantation: As part of conditioning regimens.