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Tocainide hydrochloride

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Structure

  • Tocainide hydrochloride is an amide-type antiarrhythmic agent structurally related to procainamide. It features a diethylaminoethyl side chain attached to a 2,6-dimethyl-p-aminobenzoic acid core.

  • Chemical Formula: C₁₀H₁₅N₃O₂S·HCl

    Chemical Formula of Tocainide hydrochloride
Structure of Tocainide hydrochloride
Structure of Tocainide hydrochloride

Mode of Action

  • Class IA Antiarrhythmic: Blocks fast sodium channels, prolongs action potential duration and refractory period.

  • Potassium Channel Blockade: Extends repolarization by inhibiting potassium efflux.

  • Effect on Heart Rate: Converts atrial fibrillation to sinus rhythm and prevents reentrant arrhythmias.

  • Faster Onset: Compared to procainamide, tocainide has a more rapid onset of action.

Uses of Tocainide hydrochloride

  • Ventricular Arrhythmias: Treats ventricular tachycardia and ventricular fibrillation.

  • Atrial Arrhythmias: Manages atrial fibrillation and atrial flutter.

  • Reentrant Arrhythmias Prevention: Effective in preventing recurrence post-cardiac events.

  • Antiarrhythmic Prophylaxis: Used after myocardial infarction to prevent arrhythmias.


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