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Triamterene

Structure of Triamterene

  • Triamterene is a non-steroidal potassium-sparing diuretic with a triazine ring structure attached to an aromatic moiety and amine groups.

  • Chemical Formula: C₁₆H₁₅N₃O₃

Structure of Triamterene
Structure of Triamterene

Mode of Action

  • ENaC Inhibition: Blocks epithelial sodium channels (ENaC) in the collecting ducts, reducing sodium reabsorption.

  • Potassium Retention: Promotes potassium retention by minimizing its excretion.

  • Sodium Excretion: Enhances excretion of sodium and water without significant loss of potassium.

Uses

  1. Edema: Treats fluid retention in conditions like congestive heart failure and renal disease.

  2. Hypertension: Lowers blood pressure by promoting sodium excretion.

  3. Diuretic Combinations: Often combined with thiazides to enhance diuretic efficacy and prevent hypokalemia.


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