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Types of Antianginal Drugs

I.  VASODILATORS

  • Vasodilators are also known as organic nitrates (Types of Antianginal Drugs).

MECHANISM OF ACTION

  • The prodrugs that are sources of organic nitrate are NO-producing prodrugs.

  • The soluble isoforms of guanylyl cyclase are activated by NO, which raises the amounts of cGMP inside of cells.

  • cGMP, in turn, encourages the dephosphorylation of the myosin light chain, lowers cytosolic Ca++, and causes smooth muscle cells to relax in a variety of conditions.

  • The direct relaxing effects of organic nitrate on vascular smooth muscles promote myocardial oxygenation through the dilatation of coronary arteries.

EFFECTS OF VASODILATORS

  • It increases dilation by decreasing contraction.

ADVERSE EFFECTS OF VASODILATORS

  • Headache is the most common adverse effects.

  • It also causes facial flushing, hypotension, weakness, sweating etc.

Classification of Vasodilators

Here is the mind map illustrating the classification of the mentioned vasodilators:


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