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Types of Microbial Contaminants

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1) Bacteria

Gram-Positive Bacteria

  • Examples: Staphylococcus aureus, Bacillus subtilis.

  • Characteristics: Resistant to drying; some form spores.

Gram-Negative Bacteria

  • Examples: Pseudomonas aeruginosa, Escherichia coli.

  • Characteristics: Often found in water; can be resistant to preservatives.

  • Different types of Bacteria
    Illustration of Different types of Bacteria

2) Fungi

Molds

  • Examples: Aspergillus niger, Penicillium species.

  • Characteristics: Produce spores; can grow in low aw environments.

Yeasts

  • Examples: Candida albicans, Saccharomyces cerevisiae.

  • Characteristics: Can grow in acidic environments; cause fermentation.

3) Spores

  • Definition: Dormant, resistant forms of bacteria and fungi.

  • Impact: Resistant to heat and chemical disinfectants.

  • Control: Requires stringent sterilization methods like autoclaving.

4) Viruses and Mycoplasmas

  • Less Common: Generally, not a major concern in pharmaceutical spoilage but important in biological products.

  • Above are the different Types of Microbial Contaminants

Viruses and Spores
Illustration of viruses and spores

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