Verapamil

Structure of Verapamil

• Verapamil is a phenylalkylamine derivative featuring a benzene ring connected to a dihydropyridine moiety through a methoxyethyl bridge.

• Chemical Formula: C₂₂H₂₉N₃O₄

Structure of Verapamil

Mode of Action

• Calcium Channel Blocking: Inhibits L-type calcium channels in cardiac and smooth muscle cells.

• Negative Inotropic Effect: Decreases myocardial contractility.

• Negative Chronotropic Effect: Reduces heart rate by slowing sinoatrial node activity.

• Vasodilation: Lowers blood pressure by relaxing vascular smooth muscle.

Uses

1. Hypertension: Lowers blood pressure by causing vasodilation.

2. Angina Pectoris: Reduces myocardial oxygen demand and increases oxygen supply.

3. Arrhythmias: Treats supraventricular tachycardias by slowing AV node conduction.

4. Migraine Prophylaxis: Prevents the onset of migraines.

5. Cluster Headaches: Used as a preventive measure.