Vinblastine Sulphate

Structure of Vinblastine Sulfate

• Vinblastine Sulfate is a vinca alkaloid comprising two monomers: catharanthine and vindoline, linked together.

• Chemical Formula: C₄₈H₅₈N₁₄O₁₂

Structure of Vinblastine Sulfate

Mode of Action

• Microtubule Inhibition: Binds to tubulin, preventing microtubule assembly and disassembly.

• Mitotic Arrest: Halts cell division at metaphase by disrupting spindle formation.

• Apoptosis Induction: Leads to programmed cell death in rapidly dividing cells.

Uses

1. Hodgkin's Lymphoma: Often part of ABVD regimen.

2. Non-Hodgkin's Lymphoma: In various treatment protocols.

3. Breast Cancer: Especially metastatic cases.

4. Testicular Cancer: In combination with other chemotherapeutic agents.

5. Bladder Cancer: As part of multi-agent chemotherapy regimens.