Structure of Vinblastine Sulfate
Vinblastine Sulfate is a vinca alkaloid comprising two monomers: catharanthine and vindoline, linked together.
Chemical Formula: C₄₈H₅₈N₁₄O₁₂
Mode of Action
Microtubule Inhibition: Binds to tubulin, preventing microtubule assembly and disassembly.
Mitotic Arrest: Halts cell division at metaphase by disrupting spindle formation.
Apoptosis Induction: Leads to programmed cell death in rapidly dividing cells.
Uses
Hodgkin's Lymphoma: Often part of ABVD regimen.
Non-Hodgkin's Lymphoma: In various treatment protocols.
Breast Cancer: Especially metastatic cases.
Testicular Cancer: In combination with other chemotherapeutic agents.
Bladder Cancer: As part of multi-agent chemotherapy regimens.