M.Pharm Semester 1 · Pharmaceutical Chemistry: Advanced Medicinal Chemistry notes. Advanced Medicinal Chemistry connects rational design with the modification of molecular structures. Compare the reasoning behind a proposed change with the evidence used to evaluate it.

What to revise

  • Design: distinguish leads, analogues and prodrug concepts.
  • Targets: connect structural features with enzyme-inhibitor ideas.
  • Molecular forms: organise peptides and peptidomimetics beside their design aims.

A quick self-check

Choose a lead-to-analogue example from class. Mark the structural change and write the property it was intended to influence, keeping hypothesis and result separate.

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