Griseofulvin

Chemical Structure / Formula of Griseofulvin

  • Formula: C₁₇H₁₇ClO₆
  • Structure: A benzofuran derivative with a chlorinated ring system.

Griseofulvin

Mechanism of Action

  • Binds to fungal microtubules, inhibiting mitosis.
  • Deposited in keratin-rich tissues (nails, skin, hair), preventing fungal growth.

Uses of Griseofulvin

  • Dermatophytic infections (tinea, ringworm, athlete’s foot, onychomycosis).

Side Effects

  • Hepatotoxicity, GI upset, photosensitivity.
  • Induces CYP450 (drug interactions).

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