Methods of preparations suppositories

• Several methods exist for preparing suppositories, each with pros and cons.
• The choice of method depends on factors like the base type, drug solubility, stability, and available equipment.
• Below are the main methods:

1. Hand Molding

• Used for small-scale preparation in pharmacy settings.
• Involves manually shaping the suppository.

Steps:

• Melt the suppository base in a water bath.
• Mix in the active ingredient evenly.
• Let the mixture cool to a moldable consistency.
• Shape the suppository manually using a spatula or mold.
• Allow to harden before packaging or use.

2. Compression Molding

• Ideal for large-scale production and works with both lipophilic and hydrophilic bases.
• Involves compressing the mixture into molds using a machine.

Steps:

• Mix the active ingredient with the suppository base in powder or granule form.
• Load the mixture into a compression machine.
• Compress the mixture into molds.
• Remove and package the suppositories.

3. Fusion (Melt) Molding

• The most common method, suitable for lipophilic bases.
• Involves pouring molten mixture into molds.

Steps:

• Melt the suppository base.
• Incorporate the active ingredient evenly.
• Pour the molten mixture into a mold, avoiding air bubbles.
• Allow to cool and harden.
• Remove from the mold and package.

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