Minocycline

Chemical Structure / Formula of Minocycline

  • Formula: C23H27N3O7
  • More lipophilic than tetracycline, leading to better CNS penetration.

Minocycline

Mechanism of Action

  • Binds to 30S ribosome, blocking protein synthesis.
  • Has anti-inflammatory and neuroprotective properties in addition to antibacterial effects.

Uses of Minocycline

  • Treats acne, meningococcal carriers, MRSA, and skin infections.
  • Investigated for neurodegenerative diseases (e.g., ALS, Huntington’s disease).

Side Effects

  • Vestibular toxicity (dizziness, vertigo).
  • Hyperpigmentation (skin, gums, and sclera discoloration).
  • Autoimmune reactions (drug-induced lupus, serum sickness).

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