Norfloxacin

Chemical Structure / Formula of Norfloxacin

  • Formula: C₁₆H₁₈FN₃O₃
  • Structure: A fluorinated quinolone (fluoroquinolone), improving potency and spectrum.

Norfloxacin

Mechanism of Action

  • Inhibits DNA gyrase and topoisomerase IV, leading to bacterial DNA fragmentation and death.

Uses of Norfloxacin

  • Used for UTIs, prostatitis, and some GI infections (traveler’s diarrhea).
  • Limited systemic use due to poor tissue penetration.

Side Effects

  • GI disturbances, dizziness, headache.
  • Tendon rupture (especially in elderly and corticosteroid users).
  • QT prolongation, photosensitivity.

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