Trimethoprim

Chemical Structure / Formula of Trimethoprim

  • Formula: C₁₄H₁₈N₄O₃
  • Structure: Pyrimidine derivative.

Trimethoprim

Mechanism of Action

  • Inhibits dihydrofolate reductase (DHFR), blocking bacterial DNA synthesis.

Uses

Side Effects

  • Megaloblastic anemia, hyperkalemia, GI upset.

Synthesis of Trimethoprim

Synthesis of Trimethoprim

Structure-Activity Relationship (SAR) of Trimethoprim

Structural Feature SAR Insight
2,4-diaminopyrimidine ring Essential for binding to dihydrofolate reductase (DHFR).
Substituted benzyl group Increases selectivity for bacterial over human DHFR.
Electron-donating groups (methoxy) Improve potency and enhance lipophilicity.
Bulky side chains May hinder target binding or reduce specificity.

 

Click Here to Watch the Best Pharma Videos

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.