M.Pharm Semester 2 · Pharmacology: Principles of Drug Discovery notes. Principles of Drug Discovery connects target selection, lead finding and evaluation. A promising idea becomes stronger when its assumptions are tested rather than merely repeated.

What to revise

  • Discovery: distinguish target, hit and lead concepts.
  • Design: connect molecular modelling and QSAR with hypothesis generation.
  • Evaluation: separate predicted properties from measured evidence.

A quick self-check

Map a fictional discovery sequence from question to lead evaluation. Add one decision and the evidence required before moving to the next stage.

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